New Standardized Stromal Activation Technology
ELEA is a medical device that revolutionizes the treatment of autologous adipose tissue.
Through a mechanical and automated process, it stimulates and promotes the natural regeneration of tissues.
ELEA raises the standards of regenerative medicine.
ELEA employs minimal mechanical manipulation and is operator-independent to reliably and reproducibly activate the regenerative potential of adipose tissue.
Orbital stimulation activates stromal cells without compromising tissue morphology, resulting in a tissue enriched with growth factors and the cellular microenvironment necessary to transform regenerative potential into an effective and repeatable process.
Enhanced tissue regeneration
Perfect reproducibility
Intact extra-cellular matrix
Independent Operator
Scientific Evidence of Fat Treated with ELEA
Morphological studies on adipose tissue treated with ELEA show that the manipulation does not alter the architecture of the tissue: the adipocytes are morphologically intact and viable, while the vascular-stromal fraction retains its structure, with perfectly preserved plasma membranes and collagen scaffolds. In culture, cells from treated samples show greater stability and proliferative capacity than controls, with more regular and constant growth.
This evidence indicates that activation of adipose tissue by ELEA not only preserves its structural characteristics, but also promotes its anti-inflammatory and regenerative properties. In addition, the extracellular vesicles of the treated tissue are increased in size and bioactive content (proteins, miRNAs and other regulatory molecules), suggesting an active role of ELEA in modulating the molecular mediators involved in regenerative processes.
The ELEA Procedure
The ELEA procedure was designed with the aim of implementing regenerative processes in damaged tissue, reducing operating time, optimising workflow and ensuring consistent and reproducible results over time. Thanks to an innovative and patented approach, ELEA improves the effectiveness of interventions, ensuring high and reliable performance in every application.
The procedure takes place in a closed circuit, in a single surgical time, and can be performed in the operating theatre or in an outpatient surgical clinic (in compliance with the various types of accreditation provided for by individual regional regulations).
Step 1- Liposuction
Step 2 – Docking
Step 3 – Activation
Step 4 – Administration
Kits for different surgical disciplines
ELEA is available in four lines of pre-assembled kits, designed to meet the specific needs of the main surgical specialities: Plastic Surgery, Endoscopy, General Surgery and Orthopaedics.
ELEA Kits are distinguished by their versatility, effectively adapting to different surgical specialities and responding to a wide range of operative needs, ensuring a consistently effective application.
Each kit is designed to guarantee standardised performance and precision, meeting the most complex requirements of each area of application.
Kit Plastic Surgery
Plastic Surgery, Vulnology
Kit Endoscopy
Digestive Endoscopy, Proctology
Kit General Surgery
General Surgery, Gynaecology, Urology, Pain Therapy, ENT, Proctology
Kit Orthopaedics
Orthopaedics, Traumatology
Latest scientific works
Mechanically Activated Adipose Tissue as source for I Therapies In Neurological Disease/Injury
Current Stem Cell Research & Therapy – Unline – 2023 (Alfredo Gorio, Hongkun Geo, Marco Klingar, Valeriano Vinci, Francesca Paino)
Mechanical Activation of Adipose Tissue and Derived Mesenchymal Stem Cells: Novel Anti-Inflammatory Properties
International Journal of Molecular Sciences – 19(1) – 2018 (Stefania Carelli, Mattia Colli, Valeriano Vinci , Fabio Caviggioli, Marco Klinger, Alfredo Gorio)
Neuroprotection, Recovery of Function and Endogenous Neurogenesis in Traumatic Spinal Cord Injury Following Transplantation of Activated Adipose Tissue
Cells – 8(4) – 2019 (Stefania Carelli, Toniella Giallongo, Federica Rey, Mattia Colli, Delfina Tosi, Gaetano Bulfamante, Anna Maria Di Giulio, Alfredo Gorio)
Autologous Fat Graft with Mechanical Activation for Chronic Ulcers A Case Report
Frontiers in Medical Case Reports – 4(3) – 2023 (Stefania Andreoletti, Riccardo Fondrini, Alessandra Veronesi, Flavio Bucci, Alfredo Gorio, Valeriano Vinci)
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